noncoding rnas and cancer

Noncoding RNAs and Cancer

The eukaryotic complexity involves the expression and regulation of genes via RNA-DNA, RNA-RNA, DNA-protein and RNA-protein interactions. Recently, the role of RNA molecules in the regulation of genes in higher organisms has become more evident, especially with the discovery that about 97% of the transcriptional output in higher organisms are represented as noncoding RNAs: rRNA, snoRNAs, tRNA, ...

Noncoding RNAs and cancer

The study of miRNAs and other noncoding RNAs has revolutionised our understanding of gene expression regulation during cancer development and progression, creating one of the fastest-growing research fields in cancer with realistic therapeutic potential. The 2011 Non-coding RNAs and Cancer Symposium hosted by the University College London Cancer Institute focused on the function and regulation ...

Noncoding RNAs and Cancer

Noncoding RNAs and Cancer

A decade after RNAi was found in mammals, clinical studies using microRNA antagonists and lipid-encapsulated siRNAs are showing promise for inhibiting hepatitis C virus replication and knocking down genes in the liver. The biggest challenge to RNA-based cancer therapeutics remains delivery into cells outside of the liver, which is critical for treating disseminated cancer. Attractive approaches...

Noncoding RNAs in Cancer Medicine

Several signalling proteins involved in cell growth and differentiation represent attractive candidate targets for cancer diagnosis and/or therapy since they can act as oncogenes. Because of their high specificity and low immunogeneicity, using artificial small noncoding RNA (ncRNAs) as therapeutics has recently become a highly promising and rapidly expanding field of interest. Indeed, ncRNAs m...

Long Noncoding RNAs as Biomarkers in Cancer

Long noncoding RNAs (lncRNAs) are a relatively well-characterized class of noncoding RNA (ncRNA) molecules, involved in the regulation of various cell processes, including transcription, intracellular trafficking, and chromosome remodeling. Their deregulation has been associated with the development and progression of various cancer types, the fact which makes them suitable as biomarkers for ca...